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Literature summary for 2.7.4.9 extracted from

  • Sato, T.; Neschadim, A.; Lavie, A.; Yanagisawa, T.; Medin, J.A.
    The engineered thymidylate kinase (TMPK)/AZT enzyme-prodrug axis offers efficient bystander cell killing for suicide gene therapy of cancer (2013), PLoS ONE, 8, e78711.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine bystander cell killing contributes to tumor regression in a xenograft model relying on the delivery of expression of the thymidylate kinase suicide gene into tumors via direct intratumoral injection of recombinant therapeutic lentivirus. The thymidylate kinase/azidothymidine enzyme-prodrug axis can be effectively utilized in suicide gene therapy of solid tumors Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell
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 Homo sapiens
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PC-3 cell
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 Homo sapiens
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