Literature summary for 2.7.4.9 extracted from

Byun, Y.; Vogel, S.R.; Phipps, A.J.; Carnrot, C.; Eriksson, S.; Tiwari, R.; Tjarks, W.
Synthesis and Biological Evaluation of Inhibitors of Thymidine Monophosphate Kinase from Bacillus anthracis (2008), Nucleosides Nucleotides Nucleic Acids, 27, 244-260.

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Inhibitors

Inhibitors	Comment	Organism	Structure
5'-deoxy-5'-[2-(methylsulfonyl)benzenesulfonylamido]thymidine	91% inhibition	Bacillus anthracis
5'-deoxy-5'-[4-(4-fluorophenyl)-(1,2,3)triazol-1-yl]thymidine	87% inhibition of enzyme activity, inhibition of Bacillus anthracis Sterne growth	Bacillus anthracis
5'-deoxy-5'-[4-(methylsulfonyl)benzenesulfonylamido]thymidine	94% inhibition	Bacillus anthracis
5'-deoxy-5'-[[2-(methylthio)anilinothiocarbonyl]amino]thymidine	84% inhibition	Bacillus anthracis
5'-deoxy-5'-[[3-(methylthio)anilinothiocarbonyl]amino]thymidine	69% inhibition of enzyme activity, inhibition of Bacillus anthracis Sterne growth	Bacillus anthracis

Organism

Organism	UniProt	Comment	Textmining
Bacillus anthracis	-	-	-

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Release 2023.1 (January 2023)