Application | Comment | Organism |
---|---|---|
additional information | Mycobacterium tuberculosis thymidine monophosphate kinase (TMPKmt) recently emerged as a potentially attractive target for the design of a novel class of antituberculosis agents. | Mycobacterium tuberculosis variant bovis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(3-amino-3-deoxy-2-O,3-N-(thiocarbonyl)-beta-D-ribofuranosyl)thymine | IC99: 500 microg/ml | Mycobacterium tuberculosis variant bovis | |
1-(3-aminomethyl-3,5-dideoxy-2-O,6-N-(thiocarbonyl)-beta-D-ribofuranosyl)thymine | IC99: 100 microg/ml | Mycobacterium tuberculosis variant bovis | |
1-[3-aminomethyl-3,5-dideoxy-2-O,6-N-(thiocarbonyl)-beta-D-ribofuranosyl]thymine | - |
Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
dTMP + ATP | Mycobacterium tuberculosis variant bovis | TMPK catalyzes the conversion of dTMP to dTDP, using ATP as its preferred phosphoryl donor. Part of the biosynthetic pathway for deoxythymidine triphosphate (dTTP). | dTDP + ADP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
- |
- |
Mycobacterium tuberculosis variant bovis | - |
BCG | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dTMP + ATP | TMPK catalyzes the conversion of dTMP to dTDP, using ATP as its preferred phosphoryl donor. Part of the biosynthetic pathway for deoxythymidine triphosphate (dTTP). | Mycobacterium tuberculosis variant bovis | dTDP + ADP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
thymidylate kinase | - |
Mycobacterium tuberculosis |
thymidylate kinase | - |
Mycobacterium tuberculosis variant bovis |
TMPKmt | - |
Mycobacterium tuberculosis |
TMPKmt | - |
Mycobacterium tuberculosis variant bovis |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0023 | - |
1-[3-aminomethyl-3,5-dideoxy-2-O,6-N-(thiocarbonyl)-beta-D-ribofuranosyl]thymine | - |
Mycobacterium tuberculosis | |
0.0023 | - |
1-(3-aminomethyl-3,5-dideoxy-2-O,6-N-(thiocarbonyl)-beta-D-ribofuranosyl)thymine | - |
Mycobacterium tuberculosis variant bovis | |
0.008 | - |
1-(3-amino-3-deoxy-2-O,3-N-(thiocarbonyl)-beta-D-ribofuranosyl)thymine | - |
Mycobacterium tuberculosis variant bovis |