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Literature summary for 2.7.4.9 extracted from

  • Ostermann, N.; Segura-Pena, D.; Meier, C.; Veit, T.; Monnerjahn, C.; Konrad, M.; Lavie, A.
    Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds (2003), Biochemistry, 42, 2568-2577.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.005
-
TMP pH 7.5, 25°C Homo sapiens
0.006
-
ATP pH 7.5, 25°C, reaction with dTMP Homo sapiens
0.008
-
3'-fluoro-3'-deoxythymidine 5'-monophosphate pH 7.5, 25°C Homo sapiens
0.012
-
3'-azido-3'-deoxythymidine 5'-monophosphate pH 7.5, 25°C Homo sapiens
0.012
-
2',3'-didehydro-2',3'-dideoxythymidine 5'-monophosphate pH 7.5, 25°C Homo sapiens
0.027
-
ATP pH 7.5, 25°C, reaction with 3'-fluoro-3'-deoxythymidine 5'-monophosphate Homo sapiens
0.033
-
ATP pH 7.5, 25°C, reaction with 2',3'-didehydro-2',3'-dideoxythymidine 5'-monophosphate Homo sapiens
0.069
-
ATP pH 7.5, 25°C, reaction with 3'-azido-3'-deoxythymidine 5'-monophosphate Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P23919
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2',3'-didehydro-2',3'-dideoxythymidine 5'-monophosphate
-
Homo sapiens ADP + 2',3'-didehydro-2',3'-dideoxythymidine 5'-diphosphate
-
?
ATP + 3'-amino-3'-deoxythymidine 5'-monophosphate
-
Homo sapiens ADP + 3'-amino-3'-deoxythymidine 5'-diphosphate
-
?
ATP + 3'-azido-3'-deoxythymidine 5'-monophosphate
-
Homo sapiens ADP + 3'-azido-3'-deoxythymidine 5'-diphosphate
-
?
ATP + 3'-fluoro-3'-deoxythymidine 5'-monophosphate
-
Homo sapiens ADP + 3'-fluoro-3'-deoxythymidine 5'-diphosphate
-
?
ATP + ddTMP
-
Homo sapiens ?
-
?
ATP + dTMP
-
Homo sapiens ADP + dTDP
-
?
additional information direct correlation between the rate of phosphorylation of an NMP and its ability to induce a closing of the enzyme‘s phosphate-binding loop Homo sapiens ?
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.01
-
3'-azido-3'-deoxythymidine 5'-monophosphate pH 7.5, 25°C Homo sapiens
0.03
-
3'-fluoro-3'-deoxythymidine 5'-monophosphate pH 7.5, 25°C Homo sapiens
0.03
-
ddTMP pH 7.5, 25°C Homo sapiens
0.09
-
2',3'-didehydro-2',3'-dideoxythymidine 5'-monophosphate pH 7.5, 25°C Homo sapiens
0.14
-
3'-amino-3'-deoxythymidine 5'-monophosphate pH 7.5, 25°C Homo sapiens
0.4
-
TMP pH 7.5, 25°C Homo sapiens