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Literature summary for 2.7.4.8 extracted from

  • Reese, M.L.; Dakoji, S.; Bredt, D.S.; Doetsch, V.
    The guanylate kinase domain of the MAGUK PSD-95 binds dynamically to a conserved motif in MAP1a (2007), Nat. Struct. Mol. Biol., 14, 155-163.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of GFP-tagged enzyme in COS cells, expression of His6-tagged and GST-tagged PSD-95 SH3-GK in Escherichia coli strain BL21(DE3) Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information construction of mutant PSD-95 SH3-GK which contains a deleterious point mutation in the C-terminal SH3 domain Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Purification (Commentary)

Purification (Comment) Organism
recombinant His6-tagged PSD-95 SH3-GK from Escherichia coli strain BL21(DE3) by nickel affinity chromatography, recombinant GST-tagged PSD-95 SH3-GK from Escherichia coli strain BL21(DE3) by glutathione affinity chromatography Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
neuron from mammalian Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information guanylate kinase binds a fragment of microtubule-associated protein-1a, i.e. MAP1a, in the GMP-binding site, the minimal GK binding site comprised by residues 1862-1878. MAP1a, which helps remodel the microtubule cytoskeleton in an activity-dependent manner, a is a common binding partner of PSD-95 GK and binds GK in an extended conformation, PSD-95 GK ligand consensus is not strongly constrained, binding via binding intermediate, structure, molecular dynamics simulation, overview Rattus norvegicus ?
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Subunits

Subunits Comment Organism
More structural model of microtubule-associated protein-1a. Domain organization of neuronal MAGUKs, overview Rattus norvegicus

Synonyms

Synonyms Comment Organism
guanylate kinase
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Rattus norvegicus
MAGUK PSD-95
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Rattus norvegicus
MAGUKs
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Rattus norvegicus
membrane-associated guanylate kinases
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Rattus norvegicus
postsynaptic density protein-95 SH3 GK
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Rattus norvegicus
PSD-95 GK
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Rattus norvegicus