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Literature summary for 2.7.4.6 extracted from
- The phosphorylation status of membrane-bound nucleoside diphosphate kinase in epithelia and the role of AMP (2009), Mol. Cell. Biochem., 329, 107-114.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Mus musculus | 5829 | - |
| cytosol | - |
Ovis aries | 5829 | - |
| membrane | - |
Mus musculus | 16020 | - |
| membrane | - |
Homo sapiens | 16020 | - |
| membrane | - |
Ovis aries | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required for activity, with no exogenous Mg2+ added, but in the absence of EDTA at low temperature the activity of membrane-bound NDPK is below the limit of detection | Mus musculus |  |
| Mg2+ | required for activity, with no exogenous Mg2+ added, but in the absence of EDTA at low temperature the activity of membrane-bound NDPK is below the limit of detection | Homo sapiens | |
| Mg2+ | required for activity, with no exogenous Mg2+ added, but in the absence of EDTA at low temperature the activity of membrane-bound NDPK is below the limit of detection | Ovis aries | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | NDPK co-immunoprecipitates reciprocally with AMP-activated kinase and is co-localised with this enzyme in human airways | ? | - |
? | |
| additional information | Homo sapiens | NDPK co-immunoprecipitates reciprocally with AMP-activated kinase and is co-localised with this enzyme in human airways | ? | - |
? | |
| additional information | Ovis aries | NDPK co-immunoprecipitates reciprocally with AMP-activated kinase and is co-localised with this enzyme in human airways | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Ovis aries | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | GTP (but not ATP) promotes serine phosphorylation of NDPK. Further rising [AMP] promotes serine phosphorylation (only with GTP) but inhibits histidine phosphorylation of NDPK from both donors, phosphorylation is inhibited when the reaction is performed in the presence of 1 mM AMP | Mus musculus |
| phosphoprotein | GTP (but not ATP) promotes serine phosphorylation of NDPK. Further rising [AMP] promotes serine phosphorylation (only with GTP) but inhibits histidine phosphorylation of NDPK from both donors, phosphorylation is inhibited when the reaction is performed in the presence of 1 mM AMP | Homo sapiens |
| phosphoprotein | GTP (but not ATP) promotes serine phosphorylation of NDPK. Further rising [AMP] promotes serine phosphorylation (only with GTP) but inhibits histidine phosphorylation of NDPK from both donors, phosphorylation is inhibited when the reaction is performed in the presence of 1 mM AMP | Ovis aries |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| airway epithelium | - |
Mus musculus | - |
| airway epithelium | - |
Homo sapiens | - |
| airway epithelium | - |
Ovis aries | - |
| bronchial epithelial cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + NDP | - |
Mus musculus | ADP + NTP | - |
? | |
| ATP + NDP | - |
Homo sapiens | ADP + NTP | - |
? | |
| ATP + NDP | - |
Ovis aries | ADP + NTP | - |
? | |
| additional information | NDPK co-immunoprecipitates reciprocally with AMP-activated kinase and is co-localised with this enzyme in human airways | Mus musculus | ? | - |
? | |
| additional information | NDPK co-immunoprecipitates reciprocally with AMP-activated kinase and is co-localised with this enzyme in human airways | Homo sapiens | ? | - |
? | |
| additional information | NDPK co-immunoprecipitates reciprocally with AMP-activated kinase and is co-localised with this enzyme in human airways | Ovis aries | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| NDPK | - |
Mus musculus |
| NDPK | - |
Homo sapiens |
| NDPK | - |
Ovis aries |
| NM23 | - |
Mus musculus |
| NM23 | - |
Homo sapiens |
| NM23 | - |
Ovis aries |
| nucleoside diphosphate kinase | - |
Mus musculus |
| nucleoside diphosphate kinase | - |
Homo sapiens |
| nucleoside diphosphate kinase | - |
Ovis aries |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
| ATP | - |
Homo sapiens | |
| ATP | - |
Ovis aries | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | in human airway cells exposed to hypoxia (3% oxygen) membrane-bound and cytosolic NDPK is inhibited | down |
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