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Literature summary for 2.7.4.6 extracted from

  • Schlattner, U.; Tokarska-Schlattner, M.; Ramirez, S.; Brueckner, A.; Kay, L.; Polge, C.; Epand, R.F.; Lee, R.M.; Lacombe, M.L.; Epand, R.M.
    Mitochondrial kinases and their molecular interaction with cardiolipin (2009), Biochim. Biophys. Acta, 1788, 2032-2047.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion located in the mitochondrial intermembrane/cristae space Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens O00746
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bladder highest expression Homo sapiens
-
kidney highest expression Homo sapiens
-
liver highest expression Homo sapiens
-
additional information HeLa cells are naturally almost devoid of NDPK-D Homo sapiens
-
prostate highest expression Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + NDP
-
Homo sapiens ADP + NTP
-
?

Subunits

Subunits Comment Organism
hexamer x-ray crystallography Homo sapiens

Synonyms

Synonyms Comment Organism
NDPK-D mitochondrial isoform of nucleoside diphosphate kinase Homo sapiens
nucleoside diphosphate kinase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens

General Information

General Information Comment Organism
physiological function NDPK-D is proposed to couple ATP export through adenine nucleotide translocator to the synthesis of the other nucleoside triphosphates e.g. GTP Homo sapiens