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Literature summary for 2.7.4.6 extracted from

  • Rumjahn, S.M.; Javed, M.A.; Wong, N.; Law, W.E.; Buxton, I.L.
    Purinergic regulation of angiogenesis by human breast carcinoma-secreted nucleoside diphosphate kinase (2007), Br. J. Cancer, 97, 1372-1380.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
ellagic acid inhibits NDPK and suppresses MDA-MB-435S cell growth Homo sapiens
epigallocatechin gallate EGCG, inhibits NDPK and suppresses MDA-MB-435S cell growth Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme is secreted Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + NDP Homo sapiens
-
ADP + NTP
-
?
additional information Homo sapiens MDA-MB-435S cell-secreted NDPK-B supports tumour formation by modulating ATP levels locally to activate endothelial cell P2Y receptor-mediated angiogenesis, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast carcinoma cell
-
Homo sapiens
-
MDA-MB-435S cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + NDP
-
Homo sapiens ADP + NTP
-
?
additional information MDA-MB-435S cell-secreted NDPK-B supports tumour formation by modulating ATP levels locally to activate endothelial cell P2Y receptor-mediated angiogenesis, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
NDPK
-
Homo sapiens
nucleoside diphosphate kinase
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.002 0.003
-
Homo sapiens ellagic acid
0.008 0.01
-
Homo sapiens epigallocatechin gallate