Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colorectal cancer cell | - |
Homo sapiens | - |
HCT-116 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1D-myo-inositol hexakisphosphate | - |
Homo sapiens | ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)-pentakisphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
inositol hexakisphosphate kinase-2 | - |
Homo sapiens |
IP6K2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | gene disruption of isoform IP6K2 in colorectal cancer cells selectively impairs p53-mediated apoptosis, instead favoring cell-cycle arrest | Homo sapiens |
physiological function | isoform IP6K2 is required for p53-mediated apoptosis and modulates the outcome of the p53 response. IP6K2 acts by binding directly to p53 and decreasing expression of proarrest gene targets such as the cyclin-dependent kinase inhibitor p21 | Homo sapiens |