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Literature summary for 2.7.4.21 extracted from

  • Sarmah, B.; Wente, S.R.
    Inositol hexakisphosphate kinase-2 acts as an effector of the vertebrate Hedgehog pathway (2010), Proc. Natl. Acad. Sci. USA, 107, 19921-19926.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.4.21

Inhibitors

Inhibitors Comment Organism Structure
N2-(3-(trifluoromethyl)benzyl)-N6-(4-nitrobenzyl)purine
-
 Danio rerio

Organism

Organism UniProt Comment Textmining
Danio rerio
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
 Danio rerio
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1D-myo-inositol hexakisphosphate
-
 Danio rerio ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)-pentakisphosphate
-
 ?

Synonyms

Synonyms Comment Organism
inositol hexakisphosphate kinase-2
-
 Danio rerio
IP6K2
-
 Danio rerio

General Information

General Information Comment Organism
malfunction isoform IP6K2 depletion inhibits Hh target gene expression. Inhibiting enzyme activity results in altered Hedgehog signal transduction. Isoform IP6K2 knockdown alters craniofacial and somite structures and inhibits the development and migration of neural crest cells Danio rerio
metabolism isoform inositol hexakisphosphate kinase-2 acts as an effector of the vertebrate Hedgehog pathway. IP6K2 activity is required at the level or downstream of Smoothened but upstream of the transcription activator Gli1 Danio rerio
physiological function isoform P6K2 activity is required for normal development of craniofacial structures, somites, and neural crest cells Danio rerio