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Literature summary for 2.7.4.21 extracted from

  • Jadav, R.S.; Chanduri, M.V.; Sengupta, S.; Bhandari, R.
    Inositol pyrophosphate synthesis by inositol hexakisphosphate kinase 1 is required for homologous recombination repair (2013), J. Biol. Chem., 288, 3312-3321.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.4.21

Protein Variants

Protein Variants Comment Organism
K226A/S334A catalytically inactive Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50000
-
 x * 50000, isoform IP6K1, SDS-PAGE Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MEF cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1D-myo-inositol hexakisphosphate
-
 Mus musculus ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)-pentakisphosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 50000, isoform IP6K1, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
inositol hexakisphosphate kinase 1 isoform Mus musculus
IP6K1 isoform Mus musculus

General Information

General Information Comment Organism
malfunction cells lacking isoform IP6K1 arrest after genotoxic stress, and markers associated with DNA repair are recruited to DNAdamage sites indicating that homologous recombination repair is initiated in these cells. However, repair does not proceed to completion. Enzyme loss increases chromosomal damage susceptibility Mus musculus
physiological function loss of inositol pyrophosphate synthesis by inositol hexakisphosphate kinase 1 impairs homologous recombination in mammalian cells, leading to increased cell death Mus musculus