Activating Compound | Comment | Organism | Structure |
---|---|---|---|
interferon beta | treatment with interferon beta enhances binding of IHPK2 to TNF receptor-associated factor 2 | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in NIH-OVCAR-3 cells | Homo sapiens |
overexpression of wild-type and inactive mutant IHPK2 in ovarian carcinoma cell lines | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of an inactive enzyme mutant, overexpression of wild-type IHPK2 sensitizes ovarian carcinoma cell lines to the growth-suppressive and apoptotic effects of interferon beta, IFN-alpha2, and gamma-irradiation. Expression of a kinase-dead mutant abrogates 50% of the apoptosis induced by IFN-beta | Mus musculus |
S347A/S359A | no IHPK2 activity | Homo sapiens |
S347A/S359A | site-directed mutagenesis, the mutant displays 3.5fold greater TAK1 activation following TNF-alpha, the mutant demonstrates a 6-10fold increase in NF-kappaB DNA binding following TNF-alpha compared with wild type IHPK2-expressing cells in which NF-kappa B DNA binding is inhibited | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | IHPK2 binds to tumor necrosis factor receptor-associated factor 2 and interferes with phosphorylation of transforming growth factor beta-activated kinase 1, TAK1, thereby inhibiting NF-kappaB signaling. IHPK2 contains two sites required for TRAF2 binding, Ser347 and Ser359. IHPK2-TRAF2 binding leads to attenuation of TAK1- and NF-kappa B-mediated signaling and is partially responsible for the apoptotic activity of IHPK2. A portion of the death-promoting function of IHPK2 is independent of its kinase activity | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | IHPK2 binds to tumor necrosis factor receptor-associated factor 2 and interferes with phosphorylation of transforming growth factor beta-activated kinase 1, TAK1, thereby inhibiting NF-kappaB signaling. IHPK2 contains two sites required for TRAF2 binding, Ser347 and Ser359. IHPK2-TRAF2 binding leads to attenuation of TAK1- and NF-kappa B-mediated signaling and is partially responsible for the apoptotic activity of IHPK2. A portion of the death-promoting function of IHPK2 is independent of its kinase activity | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IHPK2 | - |
Mus musculus |
IHPK2 | - |
Homo sapiens |
inositol hexakisphosphate kinase 2 | - |
Mus musculus |
inositol hexakisphosphate kinase 2 | - |
Homo sapiens |