Activating Compound | Comment | Organism | Structure |
---|---|---|---|
interferon-beta | induces IHPK2 activity after 4 h exposure | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli and HEK-293T cells, additionally wild-type IHPK2 and the NLS mutant is cloned into the pCXN2 mammalian expression vector and electroporated into NIH-OVCAR-3 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | NLS (nuclear localization sequence) mutant of IHPK2 (4 point mutations in the NLS) remains in the cytoplasm, even after interferon-beta treatment | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
nucleus | after treatment of transfected cells (fusion protein consisting of IKPK2 and enhanced green fluorescent protein) with interferon-beta the protein translocated to the nucleus, additionally treatment of HEK-293T cells with tamoxifen (30 microM, 24 h) causes translocation of IHPK2 into the condensing nucleus, transfection with NLS-eGFP results in restricted expression of the fusion protein in the cytoplasm in untreated and in apoptotic cells | Homo sapiens | 5634 | - |
perinuclear space | - |
Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
ovary cancer cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
IHPK2 | - |
Homo sapiens |
inositol hexakisphosphate kinase 2 | - |
Homo sapiens |