Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.4.21 extracted from

  • Morrison, B.H.; Tang, Z.; Jacobs, B.S.; Bauer, J.A.; Lindner, D.J.
    Apo2L/TRAIL induction and nuclear translocation of inositol hexakisphosphate kinase 2 during IFN-beta-induced apoptosis in ovarian carcinoma (2005), Biochem. J., 385, 595-603.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
interferon-beta induces IHPK2 activity after 4 h exposure Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli and HEK-293T cells, additionally wild-type IHPK2 and the NLS mutant is cloned into the pCXN2 mammalian expression vector and electroporated into NIH-OVCAR-3 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information NLS (nuclear localization sequence) mutant of IHPK2 (4 point mutations in the NLS) remains in the cytoplasm, even after interferon-beta treatment Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Homo sapiens 5737
-
nucleus after treatment of transfected cells (fusion protein consisting of IKPK2 and enhanced green fluorescent protein) with interferon-beta the protein translocated to the nucleus, additionally treatment of HEK-293T cells with tamoxifen (30 microM, 24 h) causes translocation of IHPK2 into the condensing nucleus, transfection with NLS-eGFP results in restricted expression of the fusion protein in the cytoplasm in untreated and in apoptotic cells Homo sapiens 5634
-
perinuclear space
-
Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
ovary cancer cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
IHPK2
-
Homo sapiens
inositol hexakisphosphate kinase 2
-
Homo sapiens