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Literature summary for 2.7.4.2 extracted from

  • Flock, G.; Baggio, L.L.; Longuet, C.; Drucker, D.J.
    Incretin receptors for glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide are essential for the sustained metabolic actions of vildagliptin in mice (2007), Diabetes, 56, 3006-3013.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
vildagliptin treatment reduces the hepatic expression of genes important for cholesterol synthesis and fatty acid oxidation, including phosphomevalonate kinase, acyl-coenzyme dehydrogenase medium chain, mevalonate (diphospho)decarboxylase, and acyl-CoA synthetase in wild-type, but not in dual incretin receptor knock-out mice Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
liver
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Mus musculus
-