Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-diphosphomevalonate | - |
Streptococcus pneumoniae | |
ADP | - |
Streptococcus pneumoniae | |
AMP-PNP | competitive dead-end inhibition vs. ATP | Streptococcus pneumoniae | |
ATP | - |
Streptococcus pneumoniae | |
mevalonate | competitive vs. phosphomevalonate, noncompetitive vs. ATP | Streptococcus pneumoniae | |
phosphomevalonate | - |
Streptococcus pneumoniae |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0042 | - |
phosphomevalonate | pH 7.0, 25°C | Streptococcus pneumoniae | |
0.012 | - |
diphosphomevalonate | pH 7.0, 25°C | Streptococcus pneumoniae | |
0.074 | - |
ATP | pH 7.0, 25°C | Streptococcus pneumoniae | |
0.35 | - |
ADP | pH 7.0, 25°C | Streptococcus pneumoniae | |
0.38 | - |
ADPbetaS | pH 7.0, 25°C | Streptococcus pneumoniae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + (R)-5-phosphomevalonate | Streptococcus pneumoniae | enzyme of mevalonate pathway | ADP + 5-diphosphomevalonate | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptococcus pneumoniae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADPbetaS + 5-diphosphomevalonate | 41fold slower kcat than with ADP | Streptococcus pneumoniae | ATPbetaS + 5-phosphomevalonate | - |
r | |
ATP + (R)-5-phosphomevalonate | enzyme of mevalonate pathway | Streptococcus pneumoniae | ADP + 5-diphosphomevalonate | - |
r | |
ATP + 5-phosphomevalonate | - |
Streptococcus pneumoniae | ADP + 5-diphosphomevalonate | - |
r |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.095 | - |
ADPbetaS | pH 7.0, 25°C | Streptococcus pneumoniae | |
3.4 | - |
ATP | pH 7.0, 25°C | Streptococcus pneumoniae | |
3.9 | - |
ADP | pH 7.0, 25°C | Streptococcus pneumoniae |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0077 | - |
phosphomevalonate | pH 7.0, 25°C | Streptococcus pneumoniae | |
0.014 | - |
5-diphosphomevalonate | pH 7.0, 25°C | Streptococcus pneumoniae | |
0.137 | - |
ATP | pH 7.0, 25°C | Streptococcus pneumoniae | |
0.41 | - |
ADP | pH 7.0, 25°C | Streptococcus pneumoniae |