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Literature summary for 2.7.4.2 extracted from

  • Shama Bhat, C.; Ramasarma, T.
    Inhibition of rat liver mevalonate pyrophosphate decarboxylase and mevalonate phosphate kinase by phenyl and phenolic compounds (1979), Biochem. J., 181, 143-151.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
4-hydroxybenzaldehyde 2.5 mM, 11% inhibition Rattus norvegicus
4-hydroxybenzoic acid 2.5 mM, 28% inhibition Rattus norvegicus
4-hydroxyphenylpropionic acid 2.5 mM, 46% inhibition Rattus norvegicus
Anisic acid 2.5 mM, 27% inhibition Rattus norvegicus
Cinnamic acid 2.5 mM, 28% inhibition Rattus norvegicus
isoferulic acid 2.5 mM, 64% inhibition Rattus norvegicus
m-coumaric acid 2.5 mM, 70% inhibition Rattus norvegicus
p-coumaric acid 1.25 mM, 46% inhibition Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 5-phosphomevalonate
-
 Rattus norvegicus ADP + 5-diphosphomevalonate
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.39
-
 p-coumaric acid pH 7.4, 37°C Rattus norvegicus
2.48
-
 Cinnamic acid pH 7.4, 37°C Rattus norvegicus
3.85
-
 isoferulic acid pH 7.4, 37°C Rattus norvegicus