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Literature summary for 2.7.4.14 extracted from

  • Liu, N.Q.; De Marchi, T.; Timmermans, A.; Trapman-Jansen, A.M.; Foekens, R.; Look, M.P.; Smid, M.; van Deurzen, C.H.; Span, P.N.; Sweep, F.C.; Brask, J.B.; Timmermans-Wielenga, V.; Foekens, J.A.; Martens, J.W.; Umar, A.
    Prognostic significance of nuclear expression of UMP-CMP kinase in triple negative breast cancer patients (2016), Sci. Rep., 6, 32027.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
diagnostics UMP-CMP kinase (CMPK1) as a prognostic marker for triple negative breast cancer. Analysis of 461 breast adenocarcinoma samples, overview. While cytoplasmic CMPK1 does not show any association to metastasis free survival (MFS), nuclear CMPK1 is associated to poor prognosis independently from other prognostic factors in stratified Cox regression analyses Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
gene CMPK1 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm cytoplasmic isozyme Homo sapiens 5737
-
nucleus nuclear isozyme Homo sapiens 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
22000
-
x * 22000 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + CMP Homo sapiens
-
ADP + CDP
-
?
ATP + UMP Homo sapiens
-
ADP + UDP
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P30085 gene CMPK1
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell distribution of the enzyme expression in different cancer tissue samples, overview Homo sapiens
-
HeLa-S3 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + CMP
-
Homo sapiens ADP + CDP
-
?
ATP + UMP
-
Homo sapiens ADP + UDP
-
?

Subunits

Subunits Comment Organism
? x * 22000 Homo sapiens

Synonyms

Synonyms Comment Organism
CMPK1
-
Homo sapiens
UMP-CMP kinase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens

General Information

General Information Comment Organism
additional information analysis of gene expression data associated to nuclear CMPK1 expression, overview Homo sapiens
physiological function the enzyme catalyzes phosphorylation of pyrimidine nucleoside monophosphates, which is essential for de novo biosynthesis of pyrimidines. Nuclear CMPK1 isozyme is indicative of poor prognosis in triple negative breast cancers, TNBC, and its expression may be related to dysregulation of extracellular matrix and cell cycle molecules, clinical significance of CMPK1 in TNBC patients., overview. CMPK1 performs a crucial role in activation of nucleoside analogues used as chemotherapy against human cancers and pathogenic viruses Homo sapiens