Application | Comment | Organism |
---|---|---|
diagnostics | UMP-CMP kinase (CMPK1) as a prognostic marker for triple negative breast cancer. Analysis of 461 breast adenocarcinoma samples, overview. While cytoplasmic CMPK1 does not show any association to metastasis free survival (MFS), nuclear CMPK1 is associated to poor prognosis independently from other prognostic factors in stratified Cox regression analyses | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
gene CMPK1 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | cytoplasmic isozyme | Homo sapiens | 5737 | - |
nucleus | nuclear isozyme | Homo sapiens | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
22000 | - |
x * 22000 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + CMP | Homo sapiens | - |
ADP + CDP | - |
? | |
ATP + UMP | Homo sapiens | - |
ADP + UDP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P30085 | gene CMPK1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | distribution of the enzyme expression in different cancer tissue samples, overview | Homo sapiens | - |
HeLa-S3 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + CMP | - |
Homo sapiens | ADP + CDP | - |
? | |
ATP + UMP | - |
Homo sapiens | ADP + UDP | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 22000 | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
CMPK1 | - |
Homo sapiens |
UMP-CMP kinase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | analysis of gene expression data associated to nuclear CMPK1 expression, overview | Homo sapiens |
physiological function | the enzyme catalyzes phosphorylation of pyrimidine nucleoside monophosphates, which is essential for de novo biosynthesis of pyrimidines. Nuclear CMPK1 isozyme is indicative of poor prognosis in triple negative breast cancers, TNBC, and its expression may be related to dysregulation of extracellular matrix and cell cycle molecules, clinical significance of CMPK1 in TNBC patients., overview. CMPK1 performs a crucial role in activation of nucleoside analogues used as chemotherapy against human cancers and pathogenic viruses | Homo sapiens |