Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CuSO4 | 0.25 mM, 96% inhibition of enzyme form UMPK1 and 92% inhibition of enzyme form UMPK2 | Homo sapiens | |
HgCl2 | 0.25 mM, complete inhibition of enzyme form UMPK1 and UMPK2 | Homo sapiens | |
lead nitrate | 0.25 mM, 52% inhibition of enzyme form UMPK1 and 40% inhibition of enzyme form UMPK2 | Homo sapiens | |
ZnCl2 | 0.25 mM, 55% inhibition of enzyme form UMPK1 and 30% inhibition of enzyme form UMPK2 | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.026 | - |
CMP | 37°C enzyme form UMPK 1 | Homo sapiens | |
0.028 | - |
CMP | 37°C, enzyme form UMPK2 | Homo sapiens | |
0.053 | - |
UMP | 37°C, enzyme form UMPK1 | Homo sapiens | |
0.064 | - |
UMP | 37°C, enzyme form UMPK2 | Homo sapiens | |
0.25 | - |
ATP | 37°C, enzyme form UMPK2 | Homo sapiens | |
0.36 | - |
ATP | 37°C, enzyme form UMPK1 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
partial, two allelic gene products UMPK1 and UMPK2 | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + AMP | - |
Homo sapiens | ADP + ADP | - |
r | |
ATP + CMP | - |
Homo sapiens | ADP + CDP | - |
? | |
ATP + dUMP | - |
Homo sapiens | ADP + dUDP | - |
? | |
ATP + UMP | - |
Homo sapiens | ADP + UDP | - |
? |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
30 min, stable | Homo sapiens |
40 | - |
30 min, enzyme form UMPK2 loses 70% of maximal activity, enzyme form UMPK1 loses 30% of its activity | Homo sapiens |
45 | - |
30 min, enzyme form UMPK2 loses more than 80% of maximal activity, enzyme form UMPK1 loses more than 60% of its activity | Homo sapiens |
50 | - |
30 min, enzyme forms UMPK2 and UMPK1 lose 90% of its activity | Homo sapiens |