Literature summary for 2.7.3.2 extracted from

Tonin, A.M.; Ferreira, G.C.; Schuck, P.F.; Viegas, C.M.; Zanatta, A.; Leipnitz, G.; Seminotti, B.; Duvall Wannmacher, C.M.; Wajner, M.
Inhibition of creatine kinase activity by lysine in rat cerebral cortex (2009), Metab. Brain Dis., 24, 349-360.

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Inhibitors

Inhibitors	Comment	Organism	Structure
L-lysine	total and cytosolic creatine kinase activities are significantly inhibited by L-lysine, in contrast to the mitochondrial isoform which is not affected, the inhibitory effect of L-lysine on total creatine kinase activity is totally prevented by reduced glutathione	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Rattus norvegicus	5829	-
mitochondrion	-	Rattus norvegicus	5739	-

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cerebral cortex	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + creatine	-	Rattus norvegicus	ADP + creatine phosphate	-	?

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Rattus norvegicus

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Release 2023.1 (January 2023)