Protein Variants | Comment | Organism |
---|---|---|
R203P | three-dimensional structure analysis, kcat is reduced by 10-20%, mostly unaltered kinetic parameter, decreased stability compared to the wild-type | Saccharomyces cerevisiae |
R206P | naturally occuring mutant variant phosphoglycerate kinase-Uppsala, associated with chronic nonspherocytic hemolytic anemia, structure study via comparison to constructed mutant analogue in yeast | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
mutant pathological variant phosphoglycerate kinase-Uppsala with R206P | - |
Saccharomyces cerevisiae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 3-phospho-D-glycerate | - |
Homo sapiens | ADP + 1,3-diphosphoglycerate | - |
r | |
ATP + 3-phospho-D-glycerate | - |
Saccharomyces cerevisiae | ADP + 1,3-diphosphoglycerate | - |
r |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ADP | - |
Homo sapiens | |
ADP | - |
Saccharomyces cerevisiae | |
ATP | required as phosphate donor | Homo sapiens | |
ATP | required as phosphate donor | Saccharomyces cerevisiae |