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Literature summary for 2.7.2.3 extracted from
- Inhibition of phosphoglycerate kinase by salicylates (1978), Biochim. Biophys. Acta, 523, 94-100.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-Hydroxy-3,5-diiodobenzoate | - |
Saccharomyces cerevisiae |  |
| 2-Hydroxy-5-iodobenzoate | - |
Saccharomyces cerevisiae | |
| salicylate | i.e. 2-hydroxybenzoate | Saccharomyces cerevisiae | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinetics | Saccharomyces cerevisiae | |
| 0.04 | - |
ATP | pH 7.8, 25°C | Saccharomyces cerevisiae | |
| 0.04 | - |
ATP | ATP in form of MgATP2- | Saccharomyces cerevisiae | |
| 3.45 | - |
dATP | pH 7.8, 25°C | Saccharomyces cerevisiae | |
| 3.45 | - |
dATP | ATP in form of MgdATP2- | Saccharomyces cerevisiae | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 3-phospho-D-glycerate | - |
Saccharomyces cerevisiae | ADP + 1,3-diphosphoglycerate | - |
r | |
| ATP + 3-phospho-D-glycerate | - |
Saccharomyces cerevisiae | ADP + 3-phospho-D-glyceroyl phosphate | - |
r | |
| dATP + 3-phospho-D-glycerate | - |
Saccharomyces cerevisiae | dADP + 1,3-diphosphoglycerate | - |
? | |
| dATP + 3-phospho-D-glycerate | - |
Saccharomyces cerevisiae | dADP + 3-phospho-D-glyceroyl phosphate | - |
r | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Saccharomyces cerevisiae |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.8 | - |
assay at | Saccharomyces cerevisiae |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ADP | - |
Saccharomyces cerevisiae | |
| ATP | true substrate is the magnesium complexes of ATP | Saccharomyces cerevisiae | |
| ATP | required as phosphate donor | Saccharomyces cerevisiae | |
| dATP | - |
Saccharomyces cerevisiae | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | inhibition kinetics | Saccharomyces cerevisiae | |
| 0.009 | - |
salicylate | versus 3-phospho-D-glycerate, pH 7.8, 25°C | Saccharomyces cerevisiae | |
| 0.011 | - |
salicylate | versus MgATP2-, plote: slope, pH 7.8, 25°C | Saccharomyces cerevisiae | |
| 0.06 | - |
2-Hydroxy-5-iodobenzoate | versus 3-phospho-D-glycerate, pH 7.8, 25°C | Saccharomyces cerevisiae | |
| 0.065 | - |
2-Hydroxy-3,5-diiodobenzoate | versus 3-phospho-D-glycerate, pH 7.8, 25°C | Saccharomyces cerevisiae | |
| 0.075 | - |
2-Hydroxy-3,5-diiodobenzoate | versus MgATP2-, pH 7.8, 25°C | Saccharomyces cerevisiae | |
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