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Literature summary for 2.7.12.2 extracted from
- Mitogen-activated protein kinase kinase signaling promotes growth and vascularization of fibrosarcoma (2008), Mol. Cancer Ther., 7, 648-658.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | MKK inhibition by anthrax lethal toxin LeTx is a broadly effective strategy for targeting neovascularization in fibrosarcomas and other similar proliferative lesions | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| anthrax lethal toxin | i.e. LeTx, inactivates MKKs, LeTx treatment reduces the levels of phosphorylated extracellular signal-regulated kinase and p38 MAPK in vitro, short treatments with LeTx only modestly affects cell proliferation, sustained treatment markedly reduces cell numbers, LeTx also substantially inhibits the extracellular release of angioproliferative factors including vascular endothelial growth factor, interleukin-8, and basic fibroblast growth factor, overview | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + ERK | Homo sapiens | - |
ADP + phospho-ERK | - |
? | |
| ATP + p38 | Homo sapiens | - |
ADP + phospho-p38 | - |
? | |
| additional information | Homo sapiens | mitogen-activated protein kinase kinase signaling promotes growth and vascularization of fibrosarcoma it is required for growth of fibrosarcoma-derived xenografts, to maintain tumor blood flow, and for vascularization of fibrosarcoma-derived xenografts, and MKK signaling is required for the release of proangiogenic factors from other sarcoma-derived cell lines, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| A-204 cell | - |
Homo sapiens | - |
| A-673 cell | - |
Homo sapiens | - |
| fibrosarcoma cell | - |
Homo sapiens | - |
| fibrous histiocytoma cell | - |
Homo sapiens | - |
| GCT cell | - |
Homo sapiens | - |
| HT-1080 cell | - |
Homo sapiens | - |
| leiomyosarcoma cell | - |
Homo sapiens | - |
| liposarcoma cell | - |
Homo sapiens | - |
| NCI cell | - |
Homo sapiens | - |
| Shac cell | - |
Homo sapiens | - |
| SK-LMS-1 cell | - |
Homo sapiens | - |
| SK-UT-1 cell | - |
Homo sapiens | - |
| SW-872 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + ERK | - |
Homo sapiens | ADP + phospho-ERK | - |
? | |
| ATP + p38 | - |
Homo sapiens | ADP + phospho-p38 | - |
? | |
| additional information | mitogen-activated protein kinase kinase signaling promotes growth and vascularization of fibrosarcoma it is required for growth of fibrosarcoma-derived xenografts, to maintain tumor blood flow, and for vascularization of fibrosarcoma-derived xenografts, and MKK signaling is required for the release of proangiogenic factors from other sarcoma-derived cell lines, overview | Homo sapiens | ? | - |
? | |
| additional information | MKK signaling is required for cell proliferation and for cytokine release in vitro | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MAPK kinase | - |
Homo sapiens |
| MKK | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
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