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Literature summary for 2.7.11.31 extracted from

  • Vazquez-Martin, A.; Oliveras-Ferraros, C.; Menendez, J.A.
    The active form of the metabolic sensor: AMP-activated protein kinase (AMPK) directly binds the mitotic apparatus and travels from centrosomes to the spindle midzone during mitosis and cytokinesis (2009), Cell Cycle, 8, 2385-2398.
    View publication on PubMed
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Localization

Localization Comment Organism GeneOntology No. Textmining
centrosome at prophase, P-AMPKalpha-Thr172 associates with the two asters of microtubules that begin to nucleate from mature centrosomes. Overlapping localization of P-AMPKalpha-Thr172 with the mitotic centrosomal Aurora-A kinase on the microtubules near the spindle poles in metaphase and in early anaphase. Localization of P-AMPKalpha-Thr172 at the central spindle and midbody persists during the furrowing process and at the completion of telophase. P-AMPKalpha-Thr172 localization at centrosomes requires dynamic microtubules Homo sapiens 5813
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
A-431 cell
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
AMP-activated protein kinase
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 Homo sapiens
AMPK
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 Homo sapiens

General Information

General Information Comment Organism
physiological function AMPK is required for proper cell division and faithful chromosomal segregation during mitosis. Active form of the alpha-catalytic AMPK subunit (P-AMPKalpha-Thr172), but not its total form (AMPKalpha), transiently associates with several mitotic structures including centrosomes, spindle poles, the central spindle midzone and the midbody throughout all of the mitotic stages and cytokinesis in human cancer-derived epithelial cells Homo sapiens