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Literature summary for 2.7.11.31 extracted from

  • Caligiuri, A.; Bertolani, C.; Guerra, C.T.; Aleffi, S.; Galastri, S.; Trappoliere, M.; Vizzutti, F.; Gelmini, S.; Laffi, G.; Pinzani, M.; Marra, F.
    Adenosine monophosphate-activated protein kinase modulates the activated phenotype of hepatic stellate cells (2008), Hepatology, 47, 668-676.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleoside i.e. AICAR, the activation of AMPK negatively modulates the activated phenotype of hepatic stellate cells, AMPKactivation does not reduce PDGF-dependent activation of extracellular signal-regulated kinase, ERK, or Akt, but blocks in cell cycle progression, physiological effects of AMPK activation and inhibition, mechanism, overview Homo sapiens
adiponectin
-
 Homo sapiens
AMP
-
 Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information AMPK silencing increases PDGF-induced proliferation of hepatic stellate cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information physiological effects of AMPK activation and inhibition, mechanism, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens AMPK is a sensor of the cellular energy status, it also exerts modulation of the fibrogenic properties of hepatic stellate cells, physiological effects of AMPK activation and inhibition, mechanism, AMPK activation regulates intracellular signaling pathways in hepatic stellate cells, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatic stellate cell
-
 Homo sapiens
-
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information AMPK is a sensor of the cellular energy status, it also exerts modulation of the fibrogenic properties of hepatic stellate cells, physiological effects of AMPK activation and inhibition, mechanism, AMPK activation regulates intracellular signaling pathways in hepatic stellate cells, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
adenosine monophosphate-activated protein kinase
-
 Homo sapiens
AMPK
-
 Homo sapiens