Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + pyruvate dehydrogenase | Homo sapiens | - |
ADP + phosphorylated pyruvate dehydrogenase | - |
? | |
additional information | Homo sapiens | the PDK/PDH pathway is reduced by 73% in non small cell lung carcinoma contributing to hypoxia-inducible factor-1 stability and aerobic glycolysis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adenocarcinoma cell | high PDK expression | Homo sapiens | - |
fibroblast | in the non small cell lung tumor-supporting stroma, reduced expression of PDK1, high PDH activity | Homo sapiens | - |
lung | PDK1 and PDH expression patterns | Homo sapiens | - |
non-small cell lung cancer cell | i.e. NSCLC, reduced PDK/PDH activity, PDK1 and PDH expression patterns | Homo sapiens | - |
squamous cell carcinoma cell | high PDK expression | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + pyruvate dehydrogenase | - |
Homo sapiens | ADP + phosphorylated pyruvate dehydrogenase | - |
? | |
additional information | the PDK/PDH pathway is reduced by 73% in non small cell lung carcinoma contributing to hypoxia-inducible factor-1 stability and aerobic glycolysis | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | PDK is a component of the pyruvate dehydrogenase complex | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
PDK | - |
Homo sapiens |
PDK1 | - |
Homo sapiens |
pyruvate dehydrogenase kinase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |