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Literature summary for 2.7.11.17 extracted from

  • Jameel, E.; Naz, H.; Khan, P.; Tarique, M.; Kumar, J.; Mumtazuddin, S.; Ahamad, S.; Islam, A.; Ahmad, F.; Hoda, N.; Hassan, M.
    Design, synthesis, and biological evaluation of pyrimidine derivatives as potential inhibitors of human calcium/calmodulin-dependent protein kinase IV (2017), Chem. Biol. Drug Des., 89, 741-754 .
    View publication on PubMed
Search for more literature for 2.7.11.17

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
4-methyl-7-([6-[(quinolin-8-yl)oxy]pyrimidin-4-yl]oxy)-2H-1-benzopyran-2-one
-
 Homo sapiens
6-[(5-methoxy-1H-benzimidazol-2-yl)sulfanyl]-N-(4-methoxyphenyl)pyrimidin-4-amine
-
 Homo sapiens
7-([6-[(5-methoxy-1H-benzimidazol-2-yl)sulfanyl]pyrimidin-4-yl]oxy)-4-methyl-2H-1-benzopyran-2-one
-
 Homo sapiens
7-[(6-chloropyrimidin-4-yl)oxy]-4-methyl-2H-1-benzopyran-2-one
-
 Homo sapiens
8-([6-[(5-methoxy-1H-benzimidazol-2-yl)sulfanyl]pyrimidin-4-yl]oxy)quinoline
-
 Homo sapiens
8-([6-[(naphthalen-2-yl)oxy]pyrimidin-4-yl]oxy)-1,4-dihydroquinoline
-
 Homo sapiens
8-[(6-chloropyrimidin-4-yl)oxy]quinoline
-
 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ calcium/calmodulin-dependent enzyme Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q16566
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-
Huh-7 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
calcium/calmodulin-dependent protein kinase IV
-
 Homo sapiens
CaMKIV
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.039
-
 pH and temperature not specified in the publication, for HuH7 cells Homo sapiens 8-[(6-chloropyrimidin-4-yl)oxy]quinoline
0.04
-
 pH and temperature not specified in the publication, for HuH7 cells: 0.04 mM Homo sapiens 8-([6-[(5-methoxy-1H-benzimidazol-2-yl)sulfanyl]pyrimidin-4-yl]oxy)quinoline
0.054
-
 pH and temperature not specified in the publication, for HuH7 cells Homo sapiens 7-([6-[(5-methoxy-1H-benzimidazol-2-yl)sulfanyl]pyrimidin-4-yl]oxy)-4-methyl-2H-1-benzopyran-2-one
0.055
-
 pH and temperature not specified in the publication, for HuH7 cells Homo sapiens 8-([6-[(naphthalen-2-yl)oxy]pyrimidin-4-yl]oxy)-1,4-dihydroquinoline
0.06
-
 pH and temperature not specified in the publication, for HuH7 cells: 0.06 mM Homo sapiens 6-[(5-methoxy-1H-benzimidazol-2-yl)sulfanyl]-N-(4-methoxyphenyl)pyrimidin-4-amine
0.072
-
 pH and temperature not specified in the publication, for HuH7 cells Homo sapiens 4-methyl-7-([6-[(quinolin-8-yl)oxy]pyrimidin-4-yl]oxy)-2H-1-benzopyran-2-one
0.124
-
 fpH and temperature not specified in the publication, or HuH7 cells: 0.124 mM Homo sapiens 7-[(6-chloropyrimidin-4-yl)oxy]-4-methyl-2H-1-benzopyran-2-one
0.33
-
 pH and temperature not specified in the publication, for HEH293 cells: 0.33 mM Homo sapiens 7-[(6-chloropyrimidin-4-yl)oxy]-4-methyl-2H-1-benzopyran-2-one
0.35
-
 pH and temperature not specified in the publication, for HEH293 cells Homo sapiens 4-methyl-7-([6-[(quinolin-8-yl)oxy]pyrimidin-4-yl]oxy)-2H-1-benzopyran-2-one
0.38
-
 pH and temperature not specified in the publication, for HEH293 cells Homo sapiens 8-([6-[(naphthalen-2-yl)oxy]pyrimidin-4-yl]oxy)-1,4-dihydroquinoline

General Information

General Information Comment Organism
physiological function the enzyme is associated with cerebral hypoxia, cancer, and neurodegenerative diseases Homo sapiens