Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + beta2-adrenergic receptor | Rattus norvegicus | desensitization of the receptor with subsequent decline in the stimulatory effects of beta2-adrenergic agonists over time, the receptor is involved in alveolar Na+ and water clearance | ADP + phosphorylated beta2-adrenergic receptor | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male sprague-dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
alveolar cell type I | i.e. AT1 cells, from transdifferentiation of AT2 cells | Rattus norvegicus | - |
alveolar cell type II | i.e. AT2 cells, primary cells, transdifferentiation to AT1 cells | Rattus norvegicus | - |
epithelium | analysis of GRK2 localization in alveolar epithelium | Rattus norvegicus | - |
lung | analysis of GRK2 localization in alveolar epithelium, determination of expression level | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + beta2-adrenergic receptor | - |
Rattus norvegicus | ADP + phosphorylated beta2-adrenergic receptor | - |
? | |
ATP + beta2-adrenergic receptor | desensitization of the receptor with subsequent decline in the stimulatory effects of beta2-adrenergic agonists over time, the receptor is involved in alveolar Na+ and water clearance | Rattus norvegicus | ADP + phosphorylated beta2-adrenergic receptor | - |
? |
Synonyms | Comment | Organism |
---|---|---|
G-protein receptor kinase 2 | - |
Rattus norvegicus |
GRK2 | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |