Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Rap1a | Homo sapiens | phosphorylation of Rap1a on serine 180. Phosphorylation creates potential binding sites for the adaptor protein 14-3-3 that links Rap1 to the scaffold protein KSR. Because KSR can exist as a dimer with B-Raf, this provides Rap1 an indirect link to B-Raf and the MAP kinase cascade | ADP + phosphorylated Rap1a | - |
? | |
ATP + Rap1b | Homo sapiens | phosphorylation of Rap1b on serine 179. Phosphorylation creates potential binding sites for the adaptor protein 14-3-3 that links Rap1 to the scaffold protein KSR | ADP + phosphorylated Rap1b | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P05132 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Rap1a | phosphorylation of Rap1a on serine 180. Phosphorylation creates potential binding sites for the adaptor protein 14-3-3 that links Rap1 to the scaffold protein KSR. Because KSR can exist as a dimer with B-Raf, this provides Rap1 an indirect link to B-Raf and the MAP kinase cascade | Homo sapiens | ADP + phosphorylated Rap1a | - |
? | |
ATP + Rap1a | phosphorylation of Rap1a on serine 180 | Homo sapiens | ADP + phosphorylated Rap1a | - |
? | |
ATP + Rap1b | phosphorylation of Rap1b on serine 179. Phosphorylation creates potential binding sites for the adaptor protein 14-3-3 that links Rap1 to the scaffold protein KSR | Homo sapiens | ADP + phosphorylated Rap1b | - |
? | |
ATP + Rap1b | phosphorylation of Rap1b on serine 179 | Homo sapiens | ADP + phosphorylated Rap1b | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PKA | - |
Homo sapiens |