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Literature summary for 2.7.11.11 extracted from

  • Sormus, T.; Lavogina, D.; Enkvist, E.; Uri, A.; Viht, K.
    Efficient photocaging of a tight-binding bisubstrate inhibitor of cAMP-dependent protein kinase (2019), Chem. Commun. (Camb.), 55, 11147-11150 .
    View publication on PubMed
Search for more literature for 2.7.11.11

Inhibitors

Inhibitors Comment Organism Structure
N2-(6-([N2-(9-(4-[7-(2-ethoxy-2-oxoethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]piperazin-1-yl)-9-oxononanoyl)-D-arginyl]amino)hexanoyl)-D-argininamide i.e. ARC-2116, very weak bisubstrate inhibitor of PKAcalpha Homo sapiens
N2-(6-[(N-(9-oxo-9-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]nonanoyl)-D-alanyl)amino]hexanoyl)-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-argininamide i.e. ARC-2123, photocaging of the tight-binding bisubstrate inhibitor of cAMP-dependent protein kinase (PKA) with a nitrodibenzofuran-based group fully abolishes its inhibitory potency Homo sapiens
N2-(6-[(N2-(9-oxo-9-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]nonanoyl)-D-arginyl)amino]hexanoyl)-D-argininamide i.e. ARC-1408 , photocaging of the tight-binding bisubstrate inhibitor of cAMP-dependent protein kinase (PKA) with a nitrodibenzofuran-based group fully abolishes its inhibitory potency Homo sapiens
N2-(6-[(N6-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]-N2-(9-oxo-9-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]nonanoyl)-D-lysyl)amino]hexanoyl)-D-argininamide i.e. ARC-2115, photocaging of the tight-binding bisubstrate inhibitor of cAMP-dependent protein kinase (PKA) with a nitrodibenzofuran-based group fully abolishes its inhibitory potency Homo sapiens
N2-(9-oxo-9-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]nonanoyl)-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-lysinamide i.e. ARC-1411, photocaging of the tight-binding bisubstrate inhibitor of cAMP-dependent protein kinase (PKA) with a nitrodibenzofuran-based group fully abolishes its inhibitory potency Homo sapiens
N2-[6-((N-[9-(4-(7-[(3-nitrodibenzo[b,d]furan-2-yl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl)-9-oxononanoyl]-D-alanyl)amino)hexanoyl]-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-argininamide i.e. ARC-2113, very weak bisubstrate inhibitor of PKAcalpha Homo sapiens
N6-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]-N2-(6-[(N2-(9-oxo-9-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]nonanoyl)-D-arginyl)amino]hexanoyl)-D-lysinamide i.e. ARC-2114, photocaging of the tight-binding bisubstrate inhibitor of cAMP-dependent protein kinase (PKA) with a nitrodibenzofuran-based group fully abolishes its inhibitory potency Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P17612 cAMP-dependent protein kinase catalytic subunit alpha
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Synonyms

Synonyms Comment Organism
PKACalpha
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 Homo sapiens