Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cAMP | - |
Rattus norvegicus | |
additional information | beta-adrenergic stimulation of Ser1928 phosphorylation, L-type calcium channel Cav1.2 constitutively associates with the beta2-AR and PKA to efficiently respond to beta-adrenergic activation | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | deletion of the AKAP150 gene abrogates stimulation of alpha11.2 phosphorylation on Ser1928 in vivo, overview | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + A-kinase anchor protein | Rattus norvegicus | phosphorylation at Ser1928 | ADP + phosphorylated A-kinase anchor protein | - |
? | |
ATP + Cav1.2 | Rattus norvegicus | in anchoring to the L-type calcium channel Cav1.2 via A-kinase anchor protein 150 in neurons plays a critical role involving phosphorylation by the enzyme, PKA increases the activity of the L-type Ca2+ channel Cav1.2 in response to beta-adrenergic stimulation in heart and brain | ADP + phosphorylated Cav1.2 | - |
? | |
additional information | Rattus norvegicus | enzyme regulation, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male Harlan Sprague-Dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
heart | - |
Rattus norvegicus | - |
neuron | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + A-kinase anchor protein | phosphorylation at Ser1928 | Rattus norvegicus | ADP + phosphorylated A-kinase anchor protein | - |
? | |
ATP + A-kinase anchor protein | i.e. AKAP, phosphorylation at Ser1928, the rat enzyme is active with different AKAP substrate variants from different sources, overview | Rattus norvegicus | ADP + phosphorylated A-kinase anchor protein | - |
? | |
ATP + Cav1.2 | in anchoring to the L-type calcium channel Cav1.2 via A-kinase anchor protein 150 in neurons plays a critical role involving phosphorylation by the enzyme, PKA increases the activity of the L-type Ca2+ channel Cav1.2 in response to beta-adrenergic stimulation in heart and brain | Rattus norvegicus | ADP + phosphorylated Cav1.2 | - |
? | |
ATP + Cav1.2 | an L-type calcium channel Cav1.2 | Rattus norvegicus | ADP + phosphorylated Cav1.2 | - |
? | |
additional information | enzyme regulation, overview | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PKA | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |