Application | Comment | Organism |
---|---|---|
medicine | enzyme expression is inversely correlated with patient prognosis in mesenchymal, but not proneural high-grade gliomas | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + IKKalpha protein | Homo sapiens | - |
ADP + phosphorylated IKKalpha protein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + IKKalpha protein | - |
Homo sapiens | ADP + phosphorylated IKKalpha protein | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MLK4 | - |
Homo sapiens |
serine/threonine protein kinase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme silencing suppresses self-renewal, motility, tumorigenesis, and radioresistance of mesenchymal glioma stem cells via a loss of the mesenchymal signature | Homo sapiens |
physiological function | the enzyme binds and phosphorylates the nuclear factor-kappaB regulator IKKalpha, leading to activation of nuclear factor-kappaB signaling in glioma stem cells | Homo sapiens |