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Literature summary for 2.7.11.1 extracted from

  • Asano, J.; Nakano, A.; Oda, A.; Amou, H.; Hiasa, M.; Takeuchi, K.; Miki, H.; Nakamura, S.; Harada, T.; Fujii, S.; Kagawa, K.; Endo, I.; Yata, K.; Sakai, A.; Ozaki, S.; Matsumoto, T.; Abe, M.
    The serine/threonine kinase Pim-2 is a novel anti-apoptotic mediator in myeloma cells (2011), Leukemia, 25, 1182-1188.
    View publication on PubMed

Application

Application Comment Organism
medicine Pim-2 is a target for mutiple myeloma treatment Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(Z)-5-(4-propoxybenzylidene) thiazolidine-2,4-dione a Pim-2 inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 4E-BP1 protein Homo sapiens
-
ADP + phosphorylated 4E-BP1 protein
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bone marrow stromal cell
-
Homo sapiens
-
CEM cell
-
Homo sapiens
-
Colo-205 cell
-
Homo sapiens
-
HL-60 cell
-
Homo sapiens
-
IM-9 cell
-
Homo sapiens
-
INA-6 cell
-
Homo sapiens
-
KU-812F cell
-
Homo sapiens
-
lymphoid cell
-
Homo sapiens
-
marrow cell
-
Homo sapiens
-
MCF-7 cell
-
Homo sapiens
-
MG-63 cell
-
Homo sapiens
-
additional information quantitative real-time PCR expression analysis of Pim-2 in myeloid, lymphid, and multiple myeloid human cell-lines, overview Homo sapiens
-
myeloma cell interleukin-6 and TNF family cytokines, TNFalpha, BAFF and APRIL, but not IGF-1 cooperatively enhance the expression of the serine/threonine kinase Pim-2 in multiple myeloma cells Homo sapiens
-
osteoclast
-
Homo sapiens
-
RPMI-8226 cell
-
Homo sapiens
-
U-266 cell
-
Homo sapiens
-
U-937 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 4E-BP1 protein
-
Homo sapiens ADP + phosphorylated 4E-BP1 protein
-
?

Synonyms

Synonyms Comment Organism
Pim-2
-
Homo sapiens
serine/threonine kinase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens interleukin-6 and TNF family cytokines, TNFalpha, BAFF and APRIL, but not IGF-1 cooperatively enhance the expression of the serine/threonine kinase Pim-2 in multiple myeloma cells. Interleukin-6 and TNF family cytokines cooperatively enhance Pim-2 expression. Cucurbitacin I suppresses the Pim-2 upregulation by interleukin-6. Pim-2 upregulation by TNFalpha is suppressed by parthenolide. STAT3 and NF-kappaB activation mediates Pim-2 upregulation in mutiple myeloma cells up

General Information

General Information Comment Organism
malfunction Pim-2 short interfering RNA reduces mutiple myeloma cell viability in cocultures with bone marrow stromal cells and osteoclasts. Pim-2 inhibition suppresses mutiple myeloma cell survival, cooperatively with rapamycin Homo sapiens
physiological function upregulation of Pim-2 is an anti-apoptotic mechanism for mutiple myeloma cell survival Homo sapiens