Application | Comment | Organism |
---|---|---|
medicine | Pim-2 is a target for mutiple myeloma treatment | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(Z)-5-(4-propoxybenzylidene) thiazolidine-2,4-dione | a Pim-2 inhibitor | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 4E-BP1 protein | Homo sapiens | - |
ADP + phosphorylated 4E-BP1 protein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bone marrow stromal cell | - |
Homo sapiens | - |
CEM cell | - |
Homo sapiens | - |
Colo-205 cell | - |
Homo sapiens | - |
HL-60 cell | - |
Homo sapiens | - |
IM-9 cell | - |
Homo sapiens | - |
INA-6 cell | - |
Homo sapiens | - |
KU-812F cell | - |
Homo sapiens | - |
lymphoid cell | - |
Homo sapiens | - |
marrow cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
MG-63 cell | - |
Homo sapiens | - |
additional information | quantitative real-time PCR expression analysis of Pim-2 in myeloid, lymphid, and multiple myeloid human cell-lines, overview | Homo sapiens | - |
myeloma cell | interleukin-6 and TNF family cytokines, TNFalpha, BAFF and APRIL, but not IGF-1 cooperatively enhance the expression of the serine/threonine kinase Pim-2 in multiple myeloma cells | Homo sapiens | - |
osteoclast | - |
Homo sapiens | - |
RPMI-8226 cell | - |
Homo sapiens | - |
U-266 cell | - |
Homo sapiens | - |
U-937 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 4E-BP1 protein | - |
Homo sapiens | ADP + phosphorylated 4E-BP1 protein | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Pim-2 | - |
Homo sapiens |
serine/threonine kinase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | interleukin-6 and TNF family cytokines, TNFalpha, BAFF and APRIL, but not IGF-1 cooperatively enhance the expression of the serine/threonine kinase Pim-2 in multiple myeloma cells. Interleukin-6 and TNF family cytokines cooperatively enhance Pim-2 expression. Cucurbitacin I suppresses the Pim-2 upregulation by interleukin-6. Pim-2 upregulation by TNFalpha is suppressed by parthenolide. STAT3 and NF-kappaB activation mediates Pim-2 upregulation in mutiple myeloma cells | up |
General Information | Comment | Organism |
---|---|---|
malfunction | Pim-2 short interfering RNA reduces mutiple myeloma cell viability in cocultures with bone marrow stromal cells and osteoclasts. Pim-2 inhibition suppresses mutiple myeloma cell survival, cooperatively with rapamycin | Homo sapiens |
physiological function | upregulation of Pim-2 is an anti-apoptotic mechanism for mutiple myeloma cell survival | Homo sapiens |