Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Insulin | - |
Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
PH domain of Akt-1 isoform | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
photoreceptor inner segment | mainly | Rattus norvegicus | 1917 | - |
photoreceptor outer segment membrane | rod photoreceptors express all three Akt isoforms | Rattus norvegicus | 42622 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | Akt is activated by phosphorylation at Ser473, inhibition of basal level of Akt phosphorylation in phosphoinositide 3-kinase inhibitor-treated ex vivo cultures. PHLPP selectively dephosphorylates Akt2 and Akt3 and PHLPPL selectively dephosphorylates Akt1 and Akt3 | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
eye | - |
Rattus norvegicus | - |
retina | - |
Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
AKT | - |
Rattus norvegicus |
AKT1 | - |
Rattus norvegicus |
AKT2 | - |
Rattus norvegicus |
Akt3 | - |
Rattus norvegicus |
serine/threonine protein kinase B | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | inhibition of Akt activity results in the significant activation of PHLPP activity compared to insulin-treated conditions. Knocking down Akt1 does not affect photoreceptors during light stress | Rattus norvegicus |
physiological function | Akt is an important kinase that is activated by a variety of growth factors and insulin. The insulin receptor-activated phosphoinositide 3-kinase/Akt pathway and serine/threonine kinase Akt activation controls the activity of retinal serine/threonine phosphatases, PHLPP and PHLPPL, which themselves regulate the dephosphorylation of Akt isoforms, location of PHLPPL in rod photoreceptors and absence of PHLPP from rods. PHLPPL activity is regulated by all three Akt isoforms | Rattus norvegicus |