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Literature summary for 2.7.11.1 extracted from

  • Enomoto, A.; Kido, N.; Ito, M.; Morita, A.; Matsumoto, Y.; Takamatsu, N.; Hosoi, Y.; Miyagawa, K.
    Negative regulation of MEKK1/2 signaling by serine-threonine kinase 38 (STK38) (2008), Oncogene, 27, 1930-1938.
    View publication on PubMed

Application

Application Comment Organism
molecular biology STK38 interacts with the MAPKKKs MEKK1 and MEKK2 (MEKK1/2). STK38 inhibits MEKK1/2 activation without preventing MEKK1/2 binding to its substrate, SEK1. STK38 suppresses the autophosphorylation of MEKK2 without interfering with MEKK2 dimer formation, and converts MEKK2 from its phosphorylated to its nonphosphorylated form. The negative regulation of MEKK1/2 is not due to its phosphorylation by STK38. STK38 negatively regulates the activation of MEKK1/2 by direct interaction with the catalytic domain of MEKK1/2, suggesting a novel mechanism of MEKK1/2 regulation Homo sapiens

Protein Variants

Protein Variants Comment Organism
K118A kinase-inactive mutant does not inhibit MEKK1 and only weakly inhibits MEKK2 autophosphorylation Homo sapiens
additional information stk38 short hairpin RNA enhance sorbitol-induced activation of MEKK2 and phosphorylation of the downstream MAPKKs, MKK3/6 in HeLa cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q15208
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-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell
-
Homo sapiens
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HeLa cell
-
Homo sapiens
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MCF-7 cell
-
Homo sapiens
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MOLT-4 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + KKRNRRLSVA
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Homo sapiens ADP + phosphorylated-KKRNRRLSVA
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?

Synonyms

Synonyms Comment Organism
serine-threonine kinase
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Homo sapiens
STK38
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Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Homo sapiens