Application | Comment | Organism |
---|---|---|
molecular biology | STK38 interacts with the MAPKKKs MEKK1 and MEKK2 (MEKK1/2). STK38 inhibits MEKK1/2 activation without preventing MEKK1/2 binding to its substrate, SEK1. STK38 suppresses the autophosphorylation of MEKK2 without interfering with MEKK2 dimer formation, and converts MEKK2 from its phosphorylated to its nonphosphorylated form. The negative regulation of MEKK1/2 is not due to its phosphorylation by STK38. STK38 negatively regulates the activation of MEKK1/2 by direct interaction with the catalytic domain of MEKK1/2, suggesting a novel mechanism of MEKK1/2 regulation | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
K118A | kinase-inactive mutant does not inhibit MEKK1 and only weakly inhibits MEKK2 autophosphorylation | Homo sapiens |
additional information | stk38 short hairpin RNA enhance sorbitol-induced activation of MEKK2 and phosphorylation of the downstream MAPKKs, MKK3/6 in HeLa cells | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q15208 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293T cell | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
MOLT-4 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + KKRNRRLSVA | - |
Homo sapiens | ADP + phosphorylated-KKRNRRLSVA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
serine-threonine kinase | - |
Homo sapiens |
STK38 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |