Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Insulin | in healthy patients insulin strongly stimulates Akt phosphorylation, both on Ser473 and Thr308 residues. Muscle cells from diabetic patients display an impaired Akt1-Thr308 phosphorylation | Homo sapiens | |
Insulin | in healthy patients insulin strongly stimulates Akt phosphorylation, both on Ser473 and Thr308 residues. Muscle cells from diabetic patients display an impaired Akt2-Ser473 phosphorylation | Homo sapiens | |
Insulin | in healthy patients insulin strongly stimulates Akt phosphorylation, both on Ser473 and Thr308 residues. Muscle cells from diabetic patients display an impaired Akt3-Ser473 phosphorylation | Homo sapiens | |
Insulin | in healthy patients insulin strongly stimulates Akt phosphorylation, both on Ser473 and Thr308 residues. Muscle cells from diabetic patients display defective insulin action and a drastic reduction of insulin stimulated activity of all Akt isoforms | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P31749 | - |
- |
Homo sapiens | P31751 | - |
- |
Homo sapiens | Q9Y243 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | - |
Homo sapiens |
phosphoprotein | Muscle cells from diabetic patients display an impaired Akt2-Ser473 phosphorylation and a higher level of the Akt2-Ser473-specific protein phosphatase PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1) in muscle from diabetic patients | Homo sapiens |
phosphoprotein | Muscle cells from diabetic patients display an impaired Akt3-Ser473 phosphorylation and a higher level of the Akt3-Ser473-specific protein phosphatase PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1) in muscle from diabetic patients | Homo sapiens |
phosphoprotein | Muscle cells from diabetic patients display an impaired Akt3-Thr308 phosphorylation | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
muscle | - |
Homo sapiens | - |
muscle cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + glycogen synthase kinase-3 (GSK-3) fusion protein | - |
Homo sapiens | ADP + phosphorylated- glycogen synthase kinase-3 fusion protein | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AKT | - |
Homo sapiens |
AKT1 | - |
Homo sapiens |
AKT2 | - |
Homo sapiens |
Akt3 | - |
Homo sapiens |
PKB | - |
Homo sapiens |
protein kinase B | - |
Homo sapiens |
serine/threonine kinase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |