Protein Variants | Comment | Organism |
---|---|---|
additional information | CK2 induces neoplastic growth when overexpressed | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
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Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | bound to the zinc finger core at residues 105-147 and coordinated by Cys109, Cys114, Cys137 ans Cys140, of the beta subunit dimer | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | CK2 phosphorylates about 300 different cellular proteins, ranging from transcription factors to proteins involved in chromatin structure and cell division, CK2 induces neoplastic growth when overexpressed | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
constitutive enzyme | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | CK2 phosphorylates about 300 different cellular proteins, ranging from transcription factors to proteins involved in chromatin structure and cell division, CK2 induces neoplastic growth when overexpressed | Homo sapiens | ? | - |
? | |
additional information | the pleiotropic protein kinase CK2 possesses many protein interaction sites | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
tetramer | heterotetramer, the dimer of dimers shows a alpha2beta2 structure, the alpha subunit CK2alpha ist a catalytic heterodimer, the beta subunit CK2beta is a regulatory compact globular homodimer, but also functions as a multisubstrate docking platform for several other binding partners, CK2beta contains a Zn2+ bound to the zinc finger core at residues 105-147, the N-terminus of CK2beta contains ligand and protein interaction sites, e.g. the juxta-dimer interface region containing residues Asp105, Arg111, Glu115, Lys134, Asp142, and Lys147, determination by the optimal docking area method, organization and interaction motifs of CK2beta, overview | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
CK2 | - |
Homo sapiens |
protein kinase CK2 | - |
Homo sapiens |