Cloned (Comment) | Organism |
---|---|
expression of subunits CK2alpha and CK2beta, and of the CK2 holoenzyme in Escherichia coli, expression of Myc-tagged CK2beta in GV10.15 cells, expression of the human Drosophila homologue CK2ยท-Timekeeper | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | HeLa cells are depleted of CK2 subunits by treatment with CK2 antisense oligodeoxynucleotides directed against the catalytic alpha/alpha' and regulatory beta subunits prior induction of apoptosis | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | CK2 is a highly conserved serine/threonine kinase involved in several intracellular pathways, which control, among others, cell cycle, proliferation, apoptosis and transformation, overview, protein kinase AKT interacts with CK2 subunits in vivo as well as in vitro enhancing AKT activity, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + RRRDDDSDDD | a CK2-specific synthetic peptide substrate | Homo sapiens | ADP + RRRDDDphosphoSDDD | - |
? | |
additional information | CK2 is a highly conserved serine/threonine kinase involved in several intracellular pathways, which control, among others, cell cycle, proliferation, apoptosis and transformation, overview, protein kinase AKT interacts with CK2 subunits in vivo as well as in vitro enhancing AKT activity, overview | Homo sapiens | ? | - |
? | |
additional information | protein kinase AKT interacts with CK2 subunits in vivo as well as in vitro enhancing AKT activity, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
protein kinase CK2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |