Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | RSK2 is activated by phosphorylation by extracellular signal-regulated kinase 1/2 and phosphoinositide-dependent kinase 1 in response to many growth factors and peptide hormones | Mus musculus |
Cloned (Comment) | Organism |
---|---|
ectopic overexpression of RSK2 in MEF cells induces anchorage-independent cell transformation | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | knockdown of RSK2 by siRNA expression in NIH3T3 cells blocks foci formation, overview | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
kaempferol | an inhibitor of RSK2 invitro and in vivo, and suppresses proliferation and EGF-induced transformation in JB6 Cl41 cells, overview | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Mus musculus | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + histone H3 | Mus musculus | RSK2 is a key regulator of histone H3 phosphorylation | ADP + phosphorylated histone H3 | - |
? | |
additional information | Mus musculus | RSK2 is a critical serine/threonine kinase for the regulation of cell transformation, RSK is regulated by the tumor promoters epidermal growth factor EGF or 12-O-tetradecanoylphorbol-13-acetate, TPA, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | RSK2 is activated by phosphorylation by extracellular signal-regulated kinase 1/2 and phosphoinositide-dependent kinase 1 in response to many growth factors and peptide hormones | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | - |
Mus musculus | - |
JB6 Cl41 cell | - |
Mus musculus | - |
MEF cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + GST-CREB2 protein | - |
Mus musculus | ADP + phosphorylated GST-CREB2 protein | - |
? | |
ATP + GST-NFAT3D4-261-365 | - |
Mus musculus | ADP + phosphorylated GST-NFAT3D4-261-365 | - |
? | |
ATP + histone H3 | - |
Mus musculus | ADP + phosphorylated histone H3 | - |
? | |
ATP + histone H3 | RSK2 is a key regulator of histone H3 phosphorylation | Mus musculus | ADP + phosphorylated histone H3 | - |
? | |
additional information | RSK2 is a critical serine/threonine kinase for the regulation of cell transformation, RSK is regulated by the tumor promoters epidermal growth factor EGF or 12-O-tetradecanoylphorbol-13-acetate, TPA, overview | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
More | the enzyme belongs to the p90RSK, RSK, family of proteins | Mus musculus |
ribosomal S6 kinase 2 | - |
Mus musculus |
RSK2 | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |