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Literature summary for 2.7.11.1 extracted from

  • Liu, S.J.; Zhang, J.Y.; Li, H.L.; Fang, Z.Y.; Wang, Q.; Deng, H.M.; Gong, C.X.; Grundke-Iqbal, I.; Iqbal, K.; Wang, J.Z.
    Tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain (2004), J. Biol. Chem., 279, 50078-50088.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain Rattus norvegicus

Application

Application Comment Organism
medicine GSK-3 is a target for the therapeutic treatment of Alzheimer's disease and other tauopathies Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microtubule
-
Rattus norvegicus 5874
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [tau-protein] Rattus norvegicus abnormal hyperphosphorylation of tau by GSK-3 is associated with Alzheimer's disease and other tauopathies leading to neuronal degeneration ADP + O-phospho-[tau-protein]
-
?
additional information Rattus norvegicus tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain, inhibition of tau hyperphosphorylation inhibits an associated loss in spatial memory ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-
hippocampus
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + phosphoglycogen synthase peptide 2
-
Rattus norvegicus ADP + phosphorylated phosphoglycogen synthase peptide 2
-
?
ATP + [tau-protein] abnormal hyperphosphorylation of tau by GSK-3 is associated with Alzheimer's disease and other tauopathies leading to neuronal degeneration Rattus norvegicus ADP + O-phospho-[tau-protein]
-
?
ATP + [tau-protein] phosphorylation by GSK-3 at Ser404, Ser396, Ser198, Ser199, and Ser202 Rattus norvegicus ADP + O-phospho-[tau-protein]
-
?
additional information tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain, inhibition of tau hyperphosphorylation inhibits an associated loss in spatial memory Rattus norvegicus ?
-
?
additional information GSK-3 catalyzes tau phosphorylation in the brain, while it performs phosphorylation of glycogen synthase and other proteins in other tissues Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
glycogen synthase kinase-3
-
Rattus norvegicus
GSK-3
-
Rattus norvegicus
More see also EC 2.7.11.26 and EC 2.7.11.11 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Rattus norvegicus