Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain | Rattus norvegicus |
Application | Comment | Organism |
---|---|---|
medicine | GSK-3 is a target for the therapeutic treatment of Alzheimer's disease and other tauopathies | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microtubule | - |
Rattus norvegicus | 5874 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [tau-protein] | Rattus norvegicus | abnormal hyperphosphorylation of tau by GSK-3 is associated with Alzheimer's disease and other tauopathies leading to neuronal degeneration | ADP + O-phospho-[tau-protein] | - |
? | |
additional information | Rattus norvegicus | tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain, inhibition of tau hyperphosphorylation inhibits an associated loss in spatial memory | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
hippocampus | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + phosphoglycogen synthase peptide 2 | - |
Rattus norvegicus | ADP + phosphorylated phosphoglycogen synthase peptide 2 | - |
? | |
ATP + [tau-protein] | abnormal hyperphosphorylation of tau by GSK-3 is associated with Alzheimer's disease and other tauopathies leading to neuronal degeneration | Rattus norvegicus | ADP + O-phospho-[tau-protein] | - |
? | |
ATP + [tau-protein] | phosphorylation by GSK-3 at Ser404, Ser396, Ser198, Ser199, and Ser202 | Rattus norvegicus | ADP + O-phospho-[tau-protein] | - |
? | |
additional information | tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain, inhibition of tau hyperphosphorylation inhibits an associated loss in spatial memory | Rattus norvegicus | ? | - |
? | |
additional information | GSK-3 catalyzes tau phosphorylation in the brain, while it performs phosphorylation of glycogen synthase and other proteins in other tissues | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glycogen synthase kinase-3 | - |
Rattus norvegicus |
GSK-3 | - |
Rattus norvegicus |
More | see also EC 2.7.11.26 and EC 2.7.11.11 | Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |