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Literature summary for 2.7.11.1 extracted from

  • Hernandez, F.; Perez, M.; Lucas, J.J.; Mata, A.M.; Bhat, R.; Avila, J.
    Glycogen synthase kinase-3 plays a crucial role in tau exon 10 splicing and intranuclear distribution of SC35. Implications for Alzheimer's disease (2004), J. Biol. Chem., 279, 3801-3806.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
lithium after inhibition of GSK-3 in cortical neurons, the splicing factor SC35 is nuclearly redistributed and enriched in nuclear speckles and colocalizes with the kinase Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microtubule
-
Homo sapiens 5874
-
nucleus GSK-3 after cell treatment with lithium Homo sapiens 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + SC35 Homo sapiens substrate prephosphorylated SC35, SC35 is a member of the SR family of serine/arginine-rich splicing factors ADP + phosphorylated SC35
-
?
ATP + [tau-protein] Homo sapiens
-
ADP + O-phospho-[tau-protein]
-
?
additional information Homo sapiens GSK-3 affects the tau-mRNA splicing of exon 10 via phosphorylation of the splicing factors of the serine/arginine-rich splicing factor SR family, e.g. SC35, leading to priming and dislocation of the splicing factor, aberrant tau splicing contributes to tauopathies including Alzheimer's disease, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-
brain cortex
-
Homo sapiens
-
commercial preparation purified recombinant GSK-3beta Homo sapiens
-
neuron
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + RSRSRSRSRSRSPPPVSK SC35-derived peptide 180-197, recombinant GSK-3beta Homo sapiens ADP + phosphorylated RSRSRSRSRSRSPPPVSK
-
?
ATP + SC35 substrate prephosphorylated SC35, SC35 is a member of the SR family of serine/arginine-rich splicing factors Homo sapiens ADP + phosphorylated SC35
-
?
ATP + SC35 substrate prephosphorylated SC35, SC35 is a member of the SR family of serine/arginine-rich splicing factors, recombinant GSK-3beta Homo sapiens ADP + phosphorylated SC35
-
?
ATP + [tau-protein]
-
Homo sapiens ADP + O-phospho-[tau-protein]
-
?
ATP + [tau-protein] substrate of GSK-3 in brain Homo sapiens ADP + O-phospho-[tau-protein]
-
?
additional information GSK-3 affects the tau-mRNA splicing of exon 10 via phosphorylation of the splicing factors of the serine/arginine-rich splicing factor SR family, e.g. SC35, leading to priming and dislocation of the splicing factor, aberrant tau splicing contributes to tauopathies including Alzheimer's disease, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
glycogen synthase kinase-3
-
Homo sapiens
GSK-3
-
Homo sapiens
GSK-3beta
-
Homo sapiens
More see also EC 2.7.11.26 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens