Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | Ire1p spans the ER membrane or the nuclear membrane with which the ER is continuous, with its kinase domain localized in the cytoplasm or in the nucleus | Saccharomyces cerevisiae | 5737 | - |
membrane | a transmembrane enzyme | Saccharomyces cerevisiae | 16020 | - |
membrane | Ire1p spans the ER membrane or the nuclear membrane with which the ER is continuous, with its kinase domain localized in the cytoplasm or in the nucleus | Saccharomyces cerevisiae | 16020 | - |
nucleus | Ire1p spans the ER membrane or the nuclear membrane with which the ER is continuous, with its kinase domain localized in the cytoplasm or in the nucleus | Saccharomyces cerevisiae | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | Saccharomyces cerevisiae | Ire1p is required for activation of the unfolded protein response. It senses the accumulation of unfolded proteins in the ER and transmits the signal across the membrane toward the transcription machinery, possibly by phosphorylating downstream components of the UPR pathway | ADP + a phosphoprotein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | P32361 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | Ire1p oligomerizes in response to the accumulation of unfolded proteins in the ER and is phosphorylated in trans by other Ire1p molecules as a result of oligomerization | Saccharomyces cerevisiae |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | Ire1p is required for activation of the unfolded protein response. It senses the accumulation of unfolded proteins in the ER and transmits the signal across the membrane toward the transcription machinery, possibly by phosphorylating downstream components of the UPR pathway | Saccharomyces cerevisiae | ADP + a phosphoprotein | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | Ire1p oligomerizes in response to the accumulation of unfolded proteins in the ER | Saccharomyces cerevisiae |
Synonyms | Comment | Organism |
---|---|---|
Ire1p kinase | - |
Saccharomyces cerevisiae |
serine/threonine-protein kinase IRE1 precursor | - |
Saccharomyces cerevisiae |