Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
centromere | mitotic, activation of the checkpoint results in the recruitment of Bub1 to centromeres, Bub1 is recruited to kinetochores during the early stages of mitosis. A pool of Bub1 remains centromere-associated at metaphase and even until telophase | Schizosaccharomyces pombe | - |
- |
kinetochore | activation of the checkpoint results in the recruitment of Bub1 to centromeres, Bub1 is recruited to kinetochores during the early stages of mitosis. A pool of Bub1 remains centromere-associated at metaphase and even until telophase | Schizosaccharomyces pombe | 776 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | Schizosaccharomyces pombe | the enzyme is essential for the fission yeast spindle checkpoint response to spindle damage and to defects in centromere function. Activation of the checkpoint results in the recruitment of Bub1 to centromeres and a delay in the completion of mitosis. Bub1 also has a crucial role in normal, unperturbed mitoses. Loss of bub1 function causes chromosomes to lag on the anaphase spindle and an increased frequency of chromosome loss. bub1(+)function is essential to maintain correct ploidy through mitosis | ADP + a phosphoprotein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Schizosaccharomyces pombe | O94751 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | the enzyme is essential for the fission yeast spindle checkpoint response to spindle damage and to defects in centromere function. Activation of the checkpoint results in the recruitment of Bub1 to centromeres and a delay in the completion of mitosis. Bub1 also has a crucial role in normal, unperturbed mitoses. Loss of bub1 function causes chromosomes to lag on the anaphase spindle and an increased frequency of chromosome loss. bub1(+)function is essential to maintain correct ploidy through mitosis | Schizosaccharomyces pombe | ADP + a phosphoprotein | - |
? |
Synonyms | Comment | Organism |
---|---|---|
checkpoint serine/threonine-protein kinase bub1 | - |
Schizosaccharomyces pombe |