Literature summary for 2.7.11.1 extracted from

Grove, J.R.; Banerjee, P.; Balasubramanyam, A.; Coffer, P.J.; Price, D.J.; Avruch, J.; Woodgett, J.R.
Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini (1991), Mol. Cell. Biol., 11, 5541-5550.

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Protein Variants

Protein Variants	Comment	Organism
M24L	mutation in the alpha I polypeptide suppresses synthesis of the alpha II polypeptides	Homo sapiens
M24T	mutation in the alpha I polypeptide suppresses synthesis of the alpha II polypeptides	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P23443	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Homo sapiens	-

Subunits

Subunits	Comment	Organism
More	p70 S6 kinase alpha I with a calculated MW of 58946 Da consists of 525 amino acids, of which the last 502 residues are identical in sequence to the entire polypeptides encoded by the p70 S6 kinase alpha II with a calculated MW of 56153 Da. Both p70 S6 kinase polypeptides predicted by these cDNAs are present in p70 S6 kinase purified from rat liver, and each is thus expressed in vivo. The slightly longer alpha I polypeptide exhibits anomalously slow mobility on SDS-PAGE, migrating at an apparent MW of 90000 Da probably because of the presence of six consecutive Arg residues immediately following the initiator methionine	Homo sapiens

Synonyms

Synonyms	Comment	Organism
ribosomal protein S6 kinase	-	Homo sapiens

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Release 2023.1 (January 2023)