Literature summary for 2.7.11.1 extracted from

Edwards, D.C.; Gill, G.N.
Structural features of LIM kinase that control effects on the actin cytoskeleton (1999), J. Biol. Chem., 274, 11352-11361.

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Protein Variants

Protein Variants	Comment	Organism
additional information	replacement of Thr508 with 2 glutamic acid residues results in a fully active enzyme	Homo sapiens
T508V	activity is abolished	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + protein	Homo sapiens	phosphorylates and inactivates the actin binding/depolymerizing factor cofilin and induces actin cytoskeletal changes	ADP + protein tyrosine phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P53667	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	phosphorylation is an essential regulatory feature of LIM kinase, threonine 508 and the adjacent basic insert sequences of the activation loop are required for this process	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + protein	phosphorylates and inactivates the actin binding/depolymerizing factor cofilin and induces actin cytoskeletal changes	Homo sapiens	ADP + protein tyrosine phosphate	-	?

Synonyms

Synonyms	Comment	Organism
LIM domain kinase 1	-	Homo sapiens

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Release 2023.1 (January 2023)