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Literature summary for 2.7.10.1 extracted from
- Transinactivation of the epidermal growth factor receptor tyrosine kinase and focal adhesion kinase phosphorylation by dietary flavonoids: effect on invasive potential of human carcinoma cells (2004), Biochem. Pharmacol., 67, 2103-2114.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Epidermal growth factor | activates the tyrosine kinase activity of the epidermal growth factor receptor promoting cell growth | Homo sapiens |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| luteolin | dietary flavonoid, transinactivation of epidermal growth factor receptor tyrosine kinase and blocking of downstream signaling pathways activation, and cell migration in MiaPaCa-2 cells | Homo sapiens | |
| quercetin | dietary flavonoid, transinactivation of epidermal growth factor receptor tyrosine kinase and blocking of downstream signaling pathways activation, and cell migration in MiaPaCa-2 cells | Homo sapiens | |
| wogonin | slight inhibitory effect on epidermal growth factor receptor tyrosine kinase | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Homo sapiens | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | enzyme transactivation stimulates cell migration and the subsequent activation of downstream signaling pathways | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | EGFR tyrosine kinase is activated by tyrosine phosphorylation, and the activated enzyme stimulates phosphorylation of diverse cellular proteins, overview | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| A-431 cell | skin tumor cell line | Homo sapiens | - |
| MiaPaCa-2 cell | pancreas tumor cell line | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | enzyme transactivation stimulates cell migration and the subsequent activation of downstream signaling pathways | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| EGFR tyrosine kinase | - |
Homo sapiens |
| epidermal growth factor receptor tyrosine kinase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 22 | - |
assay at room temperature | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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