Literature summary for 2.7.1.94 extracted from

Chen, X.; Ying, Z.; Lin, X.; Lin, H.; Wu, J.; Li, M.; Song, L.
Acylglycerol kinase augments JAK2/STAT3 signaling in esophageal squamous cells (2013), J. Clin. Invest., 123, 2576-2589.

Search for more literature for 2.7.1.94

Application

Application	Comment	Organism
diagnostics	the enzyme AGK-based mechanism for constitutive activation of JAK2/STAT3 signaling in solid tumors and may represent a prognostic biomarker. AGK overexpression correlates with progression and poor prognosis in human esophageal squamous cell cancer cells	Homo sapiens
drug development	the enzyme AGK-based mechanism for constitutive activation of JAK2/STAT3 signaling in solid tumors and may represent a therapeutic target	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
gene agk, recombinant overexpression of FLAG-tagged AGK in ECa109 and KYSE510 cells	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	overexpression of AGK sustains constitutive JAK2/STAT3 activation, consequently promoting the cancer stem cell population and augmenting the tumorigenicity of esophageal squamous cell carcinoma cells both in vivo and in vitro. Enzyme knockout by expression of specific RNAi in esophageal squamous cell cancer cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q53H12	gene agk	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
carcinoma cell	-	Homo sapiens	-
esophageal squamous cell carcinoma cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
AGK	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	acylglycerol kinase (AGK) is a multisubstrate lipid kinase, that catalyzes the production of lysophosphatidic acid and phosphatidic acid from monoacylglycerol and diacylglycerol. Acylglycerol kinase augments JAK2/STAT3 signaling in esophageal squamous cells, the enzyme AGK directly interacts with the JH2 domain to relieve inhibition of JAK2 and activate JAK2/STAT3 signaling. AGK levels significantly correlate with increased STAT3 phosphorylation, poorer disease-free survival, and shorter overall survival in primary esophageal squamous cell cancer cell, and AGK expression is significantly correlated with JAK2/STAT3 hyperactivation in esophageal squamous cell cancer cell, as well as in lung and breast cancer. Overexpression of AGK leads to activation of EGF receptor and promotes the proliferation and migration of prostate cancer cells, suggesting that AGK might act as a potent oncogene. AGK enhances JAK2 activity by blocking JH2-mediated autoinhibition of JAK2. Solid tumor cells override the autoinhibitory effect of JH2 to maintain activation of JAK2/STAT3 signaling, mechanism, overview. Enzyme AGK is a JH2 domain-interacting protein that activates the JAK2/STAT3 pathway	Homo sapiens

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Release 2023.1 (January 2023)