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Literature summary for 2.7.1.93 extracted from

  • Rock, C.O.; Snyder, F.
    Biosynthesis of 1-alkyl-sn-glycero-3-phosphate via adenosine triphosphate:1-alkyl-sn-glycerol phosphotransferase (1974), J. Biol. Chem., 249, 5382-5387.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information not inhibited by rac-1-hexadecanoylglycerol, rac-1,2-dihexadecanoylglycerol, rac-1-hexadecyl-2-hexadecanoylglycerol or 2-hexadecylglycerol Oryctolagus cuniculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.6
-
ATP
-
Oryctolagus cuniculus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Oryctolagus cuniculus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ absolute requirement for a divalent metal ion, Mg2+ is most effective Oryctolagus cuniculus
Mn2+ about 50% as effective as Mg2+ in activation Oryctolagus cuniculus
additional information little activity with Zn2+, Ba2+, Cu2+, Ca2+, Hg2+, Sn2+, Sr2+, Ni2+, Fe2+, NaCl and KCl Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-alkyl-sn-glycerol Oryctolagus cuniculus involved in the biosynthesis of complex ether-linked glycerolipids ADP + 1-alkyl-sn-glycero-3-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
adult male New Zealand white rabbit
-

Purification (Commentary)

Purification (Comment) Organism
partial Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
harderian gland pink portions of Oryctolagus cuniculus
-

Storage Stability

Storage Stability Organism
-20°C, whole microsomal preparation, 0.25 M sucrose, 5 mM dithiothreitol, at least 2 months, stable Oryctolagus cuniculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-alkyl-sn-glycerol stereoselective transfer of the terminal phosphate of ATP to position 3 of the substrate, ATP is an absolute requirement for enzymatic activity Oryctolagus cuniculus ADP + 1-alkyl-sn-glycero-3-phosphate
-
?
ATP + 1-alkyl-sn-glycerol involved in the biosynthesis of complex ether-linked glycerolipids Oryctolagus cuniculus ADP + 1-alkyl-sn-glycero-3-phosphate
-
?
ATP + 1-O-hexadecyl-sn-glycerol
-
Oryctolagus cuniculus ADP + 1-O-hexadecyl-sn-glycero-3-phosphate
-
?
ATP + 1-octadecyl-sn-glycerol
-
Oryctolagus cuniculus ADP + 1-octadecyl-sn-glycero-3-phosphate
-
?
additional information not: alkylethylene glycols, only trace activity with 1-thio-hexadecyl-2,3-propanediol Oryctolagus cuniculus ?
-
?
additional information not: S-alkyl-alkylglycerols, 2-hexadecylglycerol, 3-hexadecyl-sn-glycerol, 1-hexadecylethylene glycol Oryctolagus cuniculus ?
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Oryctolagus cuniculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.1
-
0.1 M Tris-maleate buffer Oryctolagus cuniculus
7.1
-
no sharp pH optimum Oryctolagus cuniculus

pH Range

pH Minimum pH Maximum Comment Organism
6.1 8.1 about 66% of maximal activity at pH 6.1 and 8.1 Oryctolagus cuniculus