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Literature summary for 2.7.1.91 extracted from

  • Dickinson, A.; Meyer, M.; Pawlak, E.; Gomez, S.; Jaspers, I.; Allbritton, N.
    Analysis of sphingosine kinase activity in single natural killer cells from peripheral blood (2015), Integr. Biol., 7, 392-401.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.91

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + sphingosine Homo sapiens
-
 ADP + sphingosine 1-phosphate
-
 ?
additional information Homo sapiens the majority of NK cells analyzed have very low sphingosine 1-phosphate phosphatase activity in comparison to sphingosine kinase activity, the majority of cells do not convert sphingosine 1-phosphate to any other detectable compound ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NRA0 isozyme SPHK2; gene SphK2
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Homo sapiens Q9NYA1 isozyme SPHK1; gene SphK1
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Source Tissue

Source Tissue Comment Organism Textmining
natural killer cell the majority of NK cells analyzed have very low sphingosine 1-phosphate phosphatase activity in comparison to sphingosine kinase activity, the majority of cells do not convert sphingosine 1-phosphate to any other detectable compound Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + sphingosine
-
 Homo sapiens ADP + sphingosine 1-phosphate
-
 ?
additional information the majority of NK cells analyzed have very low sphingosine 1-phosphate phosphatase activity in comparison to sphingosine kinase activity, the majority of cells do not convert sphingosine 1-phosphate to any other detectable compound Homo sapiens ?
-
 ?
additional information use of an automated single-cell capillary electrophoresis system to characterize the sphingosine-1-phosphate pathway in single primary human NK cells from peripheral blood, method development, overview. The automated single-cell CE system increases throughput 100fold compared to that attained by non-automated systems, permitting the analysis of sufficiently large sample sizes to identify statistically significant differences of sphingosine-1-phosphate pathway signaling Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
SPHK1
-
 Homo sapiens
SPHK2
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction dysregulation of the sphingosine-1-phosphate pathway is linked to a number of immune system disorders Homo sapiens
physiological function sphingosine-1-phosphate is a lipid second messenger formed upon phosphorylation of sphingosine by sphingosine kinase and plays a crucial role in natural killer cell proliferation, migration, and cytotoxicity Homo sapiens