Literature summary for 2.7.1.91 extracted from

Park, S.W.; Kim, M.; Kim, M.; DAgati, V.D.; Lee, H.T.
Sphingosine kinase 1 protects against renal ischemia-reperfusion injury in mice by sphingosine-1-phosphate1 receptor activation (2011), Kidney Int., 80, 1315-1327.

Search for more literature for 2.7.1.91

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
kidney	-	Mus musculus	-

General Information

General Information	Comment	Organism
physiological function	mice with kidney-specific overexpression of enhanced green fluorescent protein fused to isoform SK1 have significantly improved renal function with lower plasma creatinine, renal necrosis, apoptosis, and inflammation. Overexpression of the fusion protein cultured human proximal tubule cells protects against peroxide-induced necrosis. Selective overexpression of the construct leads to increased HSP27 mRNA and protein expression in vivo and in vitro. Functional protection as well as induction of HSP27 with the construct overexpression in vivo is blocked with sphingosine-1-phosphate-1 receptor-1 antagonism	Homo sapiens
physiological function	renal ischemia-reperfusion injury induces isoform SK1, but not SK2, in the kidneys. Knockout or pharmacological inhibition of isoform SK1 increases injury after renal ischemia-reperfusion injury	Mus musculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)