Cloned (Comment) | Organism |
---|---|
expression in HEK-293 cell | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(S)-FTY720 vinylphosphonate | uncompetitive, binds to a putative allosteric site in the enzyme contingent on formation of the enzyme-sphingosine complex. (S)-FTY720 vinylphosphonate binding to and stabilization of the allosteric site might enhance the autoinhibitory effect on the enzymic activity | Homo sapiens | |
2-(4-hydroxyanilino)-4-(4-chlorophenyl)thiazole | mixed type inhibition | Homo sapiens | |
FTY720 | competitive | Homo sapiens | |
additional information | enzyme is an oligomeric protein containing noncooperative catalytic sites, the allosteric site exerts an autoinhibition of the catalytic site | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | enzyme is an oligomeric protein containing noncooperative catalytic sites, the allosteric site exerts an autoinhibition of the catalytic site | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9NYA1 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MCF-7 cell | - |
Homo sapiens | - |
Subunits | Comment | Organism |
---|---|---|
More | oligomeric protein containing noncooperative catalytic sites, the allosteric site exerts an autoinhibition of the catalytic site | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.002 | - |
FTY720 | pH 7.4, 30°C | Homo sapiens | |
0.0145 | - |
(S)-FTY720 vinylphosphonate | pH 7.4, 30°C | Homo sapiens | |
0.017 | - |
2-(4-hydroxyanilino)-4-(4-chlorophenyl)thiazole | pH 7.4, 30°C, competitive inhibition | Homo sapiens | |
0.048 | - |
2-(4-hydroxyanilino)-4-(4-chlorophenyl)thiazole | pH 7.4, 30°C, uncompetitive inhibition | Homo sapiens |